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The viral envelope contains proteins from the host cell and relatively few copies of the HIV Envelope protein, The Envelope protein, encoded by the HIV env gene, allows the virus to attach to target cells and fuse the viral envelope with the target cell's membrane releasing the viral contents into the cell and initiating the infectious cycle.Over half of the mass of the trimeric envelope spike is N-linked glycans.

This is, in turn, surrounded by the viral envelope, that is composed of the lipid bilayer taken from the membrane of a human host cell when the newly formed virus particle buds from the cell.

AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive.

Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype.

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